Drugs that tamp down inflammation within the brain might slow and even reverse the cognitive decline that comes with age. In a publication showing today within the journal Science Translational Medicine, University of California, Berkeley, and Ben-Gurion University scientists report that senile mice given one such drug had fewer indicators of brain inflammation and had been higher in a position to study new duties, changing into virtually as adept as mice half their age.
The successful treatment in mice helps a radical new view of what causes the confusion and dementia that always accompany aging. More and more analysis reveals that, with age, the filtration system that prevents infectious organisms or molecules within the blood from leaking into the mind—the so-known as a blood-brain barrier—turns into leaky, letting in chemical substances that cause inflammation and a cascade of cell death. After age 70, almost 60% of adults have leaky blood-brain limitations in response to Friedman’s magnetic resonance imaging studies.
An accompanying report paper by the two researchers and Dan Milikovsky of Ben-Gurion University shows that the inflammatory fog induced by a leaky blood-mind barrier alters the mouse mind’s normal rhythms, causing micro seizures-like events—momentary lapses within the regular rhythm within the hippocampus—that would produce a few of the signs seen in degenerative mind diseases like Alzheimer’s disease. Electroencephalograms (EEGs) revealed similar brain wave disruption, or paroxysmal slow-wave occasions, in humans with epilepsy and with cognitive dysfunction, together with Alzheimer’s and mild cognitive impairment (MCI).
Altogether, the proof points to a dysfunction within the brain’s blood filtration system as one of many earliest triggers of neurological aging,