Endometrial cancer is the common gynecological malignancy within the U.S. and the fourth most common cancer amongst women. As well as, endometrial cancer incidence rates are on the rise within the western world, suggesting that alterations in environmental elements such as diet, way of living, and the vaginal microbiome could also be vital drivers in its cause.
In a study revealed in Scientific Reports, Mayo Clinic researchers recognized a microbiome signature related to endometrial cancer, which in part, promoted by post-menopause. The major goal of the research was to understand how endometrial cancer threat factors alter the reproductive tract microbiome and endometrial cancer threat.
“If the microbiome does play a role in endometrial cancer rather beyond being a marker for it, this might have necessary implications for endometrial cancer prevention,” says Marina Walther-Antonio, Ph.D., lead writer of the Mayo Clinic research.
In accordance with Dr. Walther-Antonio, the established role of the vaginal microbiome as a key factor in vaginal and obstetric health, in addition to vaginal microbiome variations discovered between completely different ethnicities, this adds to the importance of exploring the microbiome in endometrial cancer.
The research group previously discovered microbiome differences between patients with and without endometrial cancer in uterine microbiome research revealed in 2017 that led to the development of a vaginal swab screening methodology used for endometrial cancer.”
in Total, the group verified the main recognized risk factors for endometrial cancer (postmenopausal status and obesity) and recognized excessive vaginal pH as an additional issue related to patients with endometrial cancer.